Issue 1

Journal for Veterinary Medicine, Biotechnology and Biosafety

Volume 4, Issue 1, March 2018, Pages 28–32

ISSN 2411-3174 (print version) ISSN 2411-0388 (online version)


Raksha-Slyusareva O. A. 1, Slyusarev O. A. 1, Tarasova I. A. 2, Boyeva S. S. 1, Ostapenko V. М. 3

1 Donetsk National Medical University of the Ministry of Healthcare of Ukraine,
Kramatorsk, Ukraine, e-mail:

2 SE ‘L. V. Gromashevsky Institute of Epdemiology and Infectious Diseases’
of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine

3 LLC ‘Bionaftusia’, Kyiv, Ukraine

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Citation for print version: Raksha-Slyusareva, O. A., Slyusarev, O. A., Tarasova, I. A., Boyeva, S. S. and Ostapenko, V. М. (2018) ‘The effect of food additive ‘Aquacarotin’ on main physiological body parameters in model experiments on animals’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 4(1), pp. 28–32.

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Citation for online version: Raksha-Slyusareva, O. A., Slyusarev, O. A., Tarasova, I. A., Boyeva, S. S. and Ostapenko, V. М. (2018) ‘The effect of food additive ‘Aquacarotin’ on main physiological body parameters in model experiments on animals’, Journal for Veterinary Medicine, Biotechnology and Biosafety. [Online] 4(1), pp. 28–32. Available at:

Summary. The purpose of the work was to carry out experimental studies to determine the effectiveness of the domestic vitamin complex — dietary food additives with biologically active action (DFA BAA) ‘Aquacarotin(LLC ‘Bionaftusia’, Ukraine), which contains 2% of water-soluble β-carotene (provitamin A) in combination with water soluble vitamin E and vitamin C on physiological body parameters, such as body weight, body weight gain, and peripheral blood parameters. The research was conducted on 60 males of white non-breeding rats that had not reached the age of puberty, and achieved it in the process of research. The rats were grouped into control and main groups of 30 individuals in each group. The main group of animals received DFA BAA ‘Aquacarotin’ during 3 weeks in addition to main ration, and the control group of animals were kept on a standard rat diet. The influence of DFA BAA ‘Aquacarotin’ on organism systems was evaluated with body weight, body weight gain, and peripheral blood leukogram indices. The obtained data shows positive influence of DFA BAA ‘Aquacarotin’ on such physiological parameters as body weight, body weight gain, and hematopoiesis reflected by the peripheral blood indices. Biological activity in DFA BAA ‘Aquacarotin’ on body weight appears as its significant and accelerated gaining, and body weight increases directly in the process of growth. Active body weight gaining terminated when DFA BAA Aquacarotinwas stopped to use. It is valuable that after termination of food additives’ introduction to animals’ ration, the growth of their body weight slowed down and normalized, thus, it did not continue by itself, which further proves the controllability of the DFA effect, and makes it safe for consumption. DFA BAA ‘Aquacarotin’ impacts on myelocytic and monocytic leukopoiesis more significantly, which affects increasing of the neutrophil pool, and probably increases the pool of eosinophilic granulocytes and monocytes in peripheral blood stream while increasing of lymphopoiesis. Therefore, DFA BAA ‘Aquacarotin’ is controllable and therefore safe in regard of its effect on physiological parameters, animals’ body weight gaining during growth, as well as peripheral blood parameters. The use of DFA BAA ‘Aquacarotin’ is beneficial for improving physiological body parameters (rapid increase in body weight), especially in the stage of growth. DFA BAA ‘Aquacarotin’ activates the myelocytic and monocytic leukopoiesis, which appears in increasing of macro- and microphage pool, as well as enhancement of their functional activity. The obtained data can be interesting and useful in medicine, agriculture, military affairs and nutrition technologies.

Keywords: vitamins A, E and C, dietary food additive ‘Aquacarotin’, body weight, body weight gain, white blood cells, peripheral blood leukogram


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