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Issue 2

Journal for Veterinary Medicine, Biotechnology and Biosafety

Volume 4, Issue 2, June 2018, Pages 10–13

ISSN 2411-3174 (print version) ISSN 2411-0388 (online version)

DEPENDENCE OF GENERAL ACTION AND ACUTE TOXICITY ON CHEMICAL STRUCTURE IN A ROW OF NEW DERIVATIVES OF 3-METHYL-7-SUBSTITUTED-8-N-ETHYL PIPERAZIN XANTHINE

Ponomarenko M. G., Kornienko V. I., Ponomarenko O. V., Duchenko Ye. A., Ladohubets Ye. V., Harkusha I. V.

Kharkiv State Zooveterinary Academy, Kharkiv, Ukraine, e-mail: nikitaponomarenko081990@gmail.com

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Citation for print version: Ponomarenko, M. G., Kornienko, V. I., Ponomarenko, O. V., Duchenko, Ye. A., Ladohubets, Ye. V. and Harkusha, I. V. (2018) ‘Dependence of general action and acute toxicity on chemical structure in a row of new derivatives of 3-methyl-7-substituted-8-N-ethyl piperazin xanthine’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 4(2), pp. 10–13.

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Citation for online version: Ponomarenko, M. G., Kornienko, V. I., Ponomarenko, O. V., Duchenko, Ye. A., Ladohubets, Ye. V. and Harkusha, I. V. (2018) ‘Dependence of general action and acute toxicity on chemical structure in a row of new derivatives of 3-methyl-7-substituted-8-N-ethyl piperazin xanthine’, Journal for Veterinary Medicine, Biotechnology and Biosafety. [Online] 4(2), pp. 10–13. Available at: http://jvmbbs.kharkov.ua/archive/2018/volume4/issue2/oJVMBBS_2018042_010-013.pdf

Summary. It has been established that the acute toxicity of the synthesized for the first time derivatives of 3-methyl-7-substituted-8-N-ethyl piperazin xanthine is in the range from 560 to 1325 mg/kg. In accordance with the classification of K. K. Sidorov, three compounds belong to practically non-toxic substances and four compounds are low-toxic. After a single administration of toxic doses of the studied compounds, the performed pathomorphological studies did not reveal statistically significant changes in the mass of the internal organs. The derivatives of 3-methyl-7-substituted-8-ethyl piperazin xanthine are a promising group of heterocyclic compounds to create safe anthelminthic drugs on their basis.

Keywords: 3-methyl-7-substituted-8-N-ethyl piperazin xanthine derivatives, general action, acute toxicity

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