Journal for Veterinary Medicine, Biotechnology and Biosafety
Volume
5, Issue 2, June 2019, Pages 22–25
ISSN 2411-3174 (print version) ISSN 2411-0388
(online version)
STUDY OF IMMUNOGENIC
PROPERTIES OF EXPERIMENTAL SERIES OF BIVALENT VACCINE AGAINST CARNIVOROUS
LEPTOSPIROSIS IN LABORATORY CONDITIONS
Babyuk S. Ya.
Bila Tserkva National Agrarian University, Bila
Tserkva, Ukraine, e-mail: sviyatik@gmail.com
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PDF (print version)
Citation for print version: Babyuk, S. Ya. (2019) ‘Study of immunogenic properties of
experimental series of bivalent vaccine against Carnivorous leptospirosis in
laboratory conditions’, Journal
for Veterinary Medicine, Biotechnology and Biosafety, 5(2),
pp. 22–25.
Download
PDF (online version)
Citation for online version: Babyuk, S. Ya. (2019) ‘Study of immunogenic properties of
experimental series of bivalent vaccine against Carnivorous leptospirosis in
laboratory conditions’, Journal
for Veterinary Medicine, Biotechnology and Biosafety.
[Online] 5(2), pp. 22–25. DOI: 10.36016/JVMBBS-2019-5-2-4.
Summary. Leptospirosis is an infectious natural-focal
disease of many species of animals and human with a wide range of clinical
signs. The most common serovars causing leptospirosis
in dogs are Icterohaemorrhagiae and Canicola. Analyzing the epizootic situation concerning
leptospirosis of carnivores in Ukraine, employees of the Laboratory of
Leptospirosis of Institute of Veterinary Medicine of the National Academy of
Agrarian Sciences have developed and produced successively three series of
bivalent inactivated vaccine against leptospirosis of carnivores, taking into
account the etiological structure of the disease of this animal species. The
paper presents the results of the study of three experimental series of
inactivated polyvalent vaccine against leptospirosis of carnivores regarding: pH, sterility, residual amounts of inactivant, completeness of inactivation, harmlessness and
immunogenic activity. It has been established that
according to the indicators of sterility, completeness of inactivation,
residual amount of inactivant, harmlessness and
concentration of hydrogen ions, all three series of vaccine meet the
requirements and norms of normative documentation. Intravenous administration
of all three experimental series of the vaccine to the experimental rabbits
provided the formation of specific anti-leptospirosis antibodies in the titers
corresponding to the parameters of the immunogenicity norms established in the
technical conditions of the drug.
Keywords: vaccine, leptospirosis, Icterohaemorrhagiae,
Canicola, dogs, rabbits, microscopic agglutination
test
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