Journal for Veterinary Medicine, Biotechnology and Biosafety

Volume 7, Issue 4, December 2021, Pages 8–13

ISSN 2411-3174 (print version) ISSN 2411-0388 (online version)

EFFECTIVENESS OF ALBENDAZOLE-BASED ANTI-PARASITIC
DRUGS UNDER MODERN CONDITIONS

Paliy A. P. 1, Sumakova N. V. 1, Bohach O. M. 1, Rodionova K. O. 2, Pavlichenko O. V. 3, Ihnatieva T. M. 3, Palii A. P. 3

1 National Scientific Center ‘Institute of Experimental and Clinical Veterinary Medicine’, Kharkiv, Ukraine, e-mail: paliy.dok@gmail.com

2 Odesa State Agrarian University, Odesa, Ukraine

3 State Biotechnological University, Kharkiv, Ukraine

Download PDF (print version)

Citation for print version: Paliy, A. P., Sumakova, N. V., Bohach, O. M., Rodionova, K. O., Pavlichenko, O. V., Ihnatieva, T. M. and Palii, A. P. (2021) ‘Effectiveness of albendazole-based anti-parasitic drugs under modern conditions’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 7(4), pp. 8–13.

Download PDF (online version)

Citation for online version: Paliy, A. P., Sumakova, N. V., Bohach, O. M., Rodionova, K. O., Pavlichenko, O. V., Ihnatieva, T. M. and Palii, A. P. (2021) ‘Effectiveness of albendazole-based anti-parasitic drugs under modern conditions’, Journal for Veterinary Medicine, Biotechnology and Biosafety. [Online] 7(4), pp. 8–13. DOI: 10.36016/JVMBBS-2021-7-4-2.

Summary. An important problem in veterinary medicine is still the control of parasitic diseases of farm and domestic animals. The market of antiparasitic drugs is widely represented by anthelmintics based on albendozole, both imported and domestic, but data on the effectiveness of these drugs are currently insufficient. The aim of the research was to determine in the comparative aspect the effectiveness of the use of antiparasitic drugs in different forms with the content of albendazole in different species of animals. In the previous stage of the studies the experimental animals were diagnosed with invasions. The most common infections in cattle were dictyocaulosis and fasciolosis; Trichostrongylus colubriformis, Cooperia oncophora, Oesophagostomum radiatum were not detected. No causative agent of Dictyocaulus vivaparus infection was detected in horses. The most common infection in dogs and cats was toxacariasis, and in mink the most common was infection wih Uncinaria spp. Along with this, no Taenia solium and Diphyllobothrium latum eggs were detected in dogs, and Opisthorchis felineus, Taenia solium, Diphyllobothrium latum were not detected in cats. After the use of preparative forms of albendazole in sick animals for 2–5 days, the presence of dead sexually mature nematodes and helminth eggs were noted in the feces of animals. The efficacy of albendazole drugs regarding helminthiasis in farm and domestic animals was 100%

Keywords: ruminants, horses, dogs, cats, minks, helminths

References:

Almeida, F. A., Garcia, K. C. O. D., Torgerson, P. R. and Amarante, A. F. T. (2010) ‘Multiple resistance to anthelmintics by Haemonchus contortus and Trichostrongylus colubriformis in sheep in Brazil’, Parasitology International, 59(4), pp. 622–625. doi: 10.1016/j.parint.2010.09.006.

Amarante, M. R. V., Bassetto, C. C., Neves, J. H. and Amarante, A. F. T. (2014) ‘Species-specific PCR for the identification of Cooperia curticei (Nematoda: Trichostrongylidae) in sheep’, Journal of Helminthology, 88(4), pp. 447–452. doi: 10.1017/S0022149X13000412.

Atehmengo, N. L. and Nnagbo, C. S. (2014) ‘Emerging animal parasitic diseases: A global overview and appropriate strategies for their monitoring and surveillance in Nigeria’, The Open Microbiology Journal, 8(1), pp. 87–94. doi: 10.2174/1874285801408010087.

Bahk, Y. Y., Shin, E.-H., Cho, S.-H., Ju, J.-W., Chai, J.-Y. and Kim, T.-S. (2018) ‘Prevention and control strategies for parasitic infections in the Korea Centers for Disease Control and Prevention’, The Korean Journal of Parasitology, 56(5), pp. 401–408. doi: 10.3347/kjp.2018.56.5.401.

Bogach, M. V., Paliy, A. P., Perots’ka, L. V., Pyvovarova, І. V., Stoyanova, V. Y. and Palii, A. P. (2020) ‘The influence of hydro-meteorological conditions on the spread of chicken cestodiasis’, Regulatory Mechanisms in Biosystems, 11(3), pp. 414–418. doi: 10.15421/022063.

Bogach, M., Paliy, A., Liulin, P., Perots’ka, L., Bohach, O., Pyvovarova, I. and Palii, A. (2021) ‘Parasites of domestic and wild pigeons in the south of Ukraine’, Biosystems Diversity, 29(2), pp. 135–139. doi: 10.15421/012118.

Bustnes, J. O., Erikstad, K. E., Hanssen, S. A., Tveraa, T., Folstad, I. and Skaare, J. U. (2006) ‘Anti-parasite treatment removes negative effects of environmental pollutants on reproduction in an Arctic seabird’, Proceedings of the Royal Society B: Biological Sciences, 273(1605), pp. 3117–3122. doi: 10.1098/rspb.2006.3687.

CE (The Council of Europe). (1986) European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes. (European Treaty Series, No. 123). Strasbourg: The Council of Europe. Available at: https://conventions.coe.int/treaty/en/treaties/html/123.htm.

CEC (The Council of the European Communities). (1986) ‘Council Directive 86/609/EEC of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes’, The Official Journal of the European Communities, L 358, pp. 1–28. Available at: http://data.europa.eu/eli/dir/1986/609/oj.

Charlier, J., De Waele, V., Ducheyne, E., van der Voort, M., Vande Velde, F. and Claerebout, E. (2015) ‘Decision making on helminths in cattle: Diagnostics, economics and human behaviour’, Irish Veterinary Journal, 69(1), p. 14. doi: 10.1186/s13620-016-0073-6.

Dantas-Torres, F., Ketzis, J., Mihalca, A. D., Baneth, G., Otranto, D., Tort, G. P., Watanabe, M., Linh, B. K., Inpankaew, T., Jimenez Castro, P. D., Borrás, P., Arumugam, S., Penzhorn, B. L., Ybañez, A. P., Irwin, P. and Traub, R. J. (2020) ‘TroCCAP recommendations for the diagnosis, prevention and treatment of parasitic infections in dogs and cats in the tropics’, Veterinary Parasitology, 283, p. 109167. doi: 10.1016/j.vetpar.2020.109167.

Demeler, J., Van Zeveren, A. M. J., Kleinschmidt, N., Vercruysse, J., Höglund, J., Koopmann, R., Cabaret, J., Claerebout, E., Areskog, M. and von Samson-Himmelstjerna, G. (2009) ‘Monitoring the efficacy of ivermectin and albendazole against gastro intestinal nematodes of cattle in Northern Europe’, Veterinary Parasitology, 160(1–2), pp. 109–115. doi: 10.1016/j.vetpar.2008.10.030.

Ezatpour, B., Hasanvand, A., Azami, M., Anbari, K. and Ahmadpour, F. (2015) ‘Prevalence of liver fluke infections in slaughtered animals in Lorestan, Iran’, Journal of Parasitic Diseases, 39(4), pp. 725–729. doi: 10.1007/s12639-014-0428-4.

Fitzpatrick, J. L. (2013) ‘Global food security: The impact of veterinary parasites and parasitologists’, Veterinary Parasitology, 195(3–4), pp. 233–248. doi: 10.1016/j.vetpar.2013.04.005.

García, H. H., Gonzalez, A. E., Evans, C. A. and Gilman, R. H. (2003) ‘Taenia solium cysticercosis’, The Lancet, 362(9383), pp. 547–556. doi: 10.1016/S0140-6736(03)14117-7.

Ghadirian, E. (1977) ‘Human infection with Trichostrongylus lerouxi (Biocca, Chabaud, and Ghadirian, 1974) in Iran’, The American Journal of Tropical Medicine and Hygiene, 26(6), pp. 1212–1213. doi: 10.4269/ajtmh.1977.26.1212.

Gibbons, L. M. (1981) ‘Revision of the African species of the genus Cooperia Ransom, 1907 (Nematoda, Trichostrongylidae)’, Systematic Parasitology, 2(4), pp. 219–252. doi: 10.1007/BF00009344.

Glamazdin, I. I., Arkhipov, I. A., Odoevskaja, I. M., Hiljuta, N. V., Halikov, S. S., Chistjachenko, J. S and, Dushkin, A. V. (2013) ‘Anthelmintic efficiency of medicinal forms of albendazole received on mechanochemical technologies and use of address delivery Drug Delivery System on laboratory model’ [Antigel’mintnaya effektivnostlekarstvennykh form al’bendazola, poluchennykh po mekhanokhimicheskoy tekhnologii i ispol’zovaniem adresnoy dostavki Drug Delivery System na laboratornoy modeli], Russian Journal of Parasitology [Rossiyskiy parazitologicheskiy zhurnal], 3, pp. 92–95. Available at: https://elibrary.ru/item.asp?id=20407241. [in Russian].

Halat, V. F., Berezovskyi, A. V., Soroka, N. M. and Prus, M. P. (2009) Parasitology and Invasive Animal Diseases [Parazytolohiia ta invaziini khvoroby tvaryn]. 2nd ed. Kyiv: Urozhai. ISBN 9660500769. [in Ukrainian].

Henrioud, A. N. (2011) ‘Towards sustainable parasite control practices in livestock production with emphasis in Latin America’, Veterinary Parasitology, 180(1–2), pp. 2–11. doi: 10.1016/j.vetpar.2011.05.026.

Horton, J. (2000) ‘Albendazole: A review of anthelmintic efficacy and safety in humans’, Parasitology, 121(S1), pp. S113S132. doi: 10.1017/S0031182000007290.

Ito, A. and Budke, C. M. (2014) ‘Culinary delights and travel? A review of zoonotic cestodiases and metacestodiases’, Travel Medicine and Infectious Disease, 12(6), pp. 582–591. doi: 10.1016/j.tmaid.2014.06.009.

John, D. T. and Petri, W. A. (2006) Markell and Voge’s Medical Parasitology. 9th ed. Missouri: Saunders Elsevier. ISBN 9780721647937.

Khanjari, A., Bahonar, A., Fallah, S., Bagheri, M., Alizadeh, A., Fallah, M. and Khanjari, Z. (2014) ‘Prevalence of Fasciolosis and Dicrocoeliosis in slaughtered sheep and goats in Amol Abattoir, Mazandaran, Northern Iran’, Asian Pacific Journal of Tropical Disease, 4(2), pp. 120–124. doi: 10.1016/S2222-1808(14)60327-3.

Kotel’nikov, G. A. (1984) Helminthological Examination of Animals and Environment [Gel’mintologicheskie issledovaniya zhivotnykh i okruzhayushchey sredy]. Moscow: Kolos. [in Russian].

Le Bailly, M. and Bouchet, F. (2013) ‘Diphyllobothrium in the past: Review and new records’, International Journal of Paleopathology, 3(3), pp. 182–187. doi: 10.1016/j.ijpp.2013.05.004.

Magomedov, O. A., Shamchalov, V. M., Abdulmagomedov, S. Sh., Gulachmedova, N. H. and Bakrieva, R. M. (2014) ‘Prevalence, seasonal and age dynamics of intestinal cestodose rates among sheep and goats in the mountain zone of Dagestan’ [Rasprostranenie, sezonnaya i vozrastnaya dinamika invazirovannosti kishechnymi tsestodozami ovets i koz v gornoy zone Dagestana], Theory and Practice of Parasitic Disease Control [Teoriya i praktika bor’by s parazitarnymi boleznyami], 15, pp. 139–142. Available at: https://elibrary.ru/item.asp?id=22676423. [in Russian].

Majeed, Q. A. H., Henedi, A. A. M., Alazemi, M. S. and Tahrani, L. M. A. (2015) ‘Study on parasites from farm animals in Kuwait’, Journal of the Egyptian Society of Parasitology, 45(1), pp. 71–74. doi: 10.12816/0010851.

Matos, M., Alho, A. M., Owen, S. P., Nunes, T. and Madeira de Carvalho, L. (2015) ‘Parasite control practices and public perception of parasitic diseases: A survey of dog and cat owners’, Preventive Veterinary Medicine, 122(1–2), pp. 174–180. doi: 10.1016/j.prevetmed.2015.09.006.

Pakharukova, M. Y. and Mordvinov, V. A. (2016) ‘The liver fluke Opisthorchis felineus: biology, epidemiology and carcinogenic potential’, Transactions of The Royal Society of Tropical Medicine and Hygiene, 110(1), pp. 28–36. doi: 10.1093/trstmh/trv085.

Paliy, A. P., Sumakova, N. V., Mashkey, A. M., Petrov, R. V., Paliy, A. P. and Ishchenko, K. V. (2018) ‘Contamination of animal-keeping premises with eggs of parasitic worms’, Biosystems Diversity, 26(4), pp. 327–333. doi: 10.15421/011848.

Paliy, A., Sumakova, N., Petrov, R., Shkromada, O., Ulko, L. and Palii, A. (2019) ‘Contamination of urbanized territories with eggs of helmiths of animals’, Biosystems Diversity, 27(2), pp. 118–124. doi: 10.15421/011916.

Paliy, A. P., Sumakova, N. V., Rodionova, K. O., Nalivayko, L. I., Boyko, V. S., Ihnatieva, T. M., Zhigalova, O. Ye., Dudus, T. V., Anforova, M. V., and Kazakov, M. V. (2020a) ‘Disinvasive action of aldehyde and chlorine disinfectants on the test-culture of Toxocara canis eggs’, Ukrainian Journal of Ecology, 10(4), pp. 175–183. doi: 10.15421/2020_185.

Paliy, A. P., Sumakova, N. V., Telyatnikov, A. V., Zhukova, I. O., Kasianenko, O. I., Shkromada, O. I., Suprun, Yu. O., Plyuta, L. V., Yevtushenko, I. D., Kovalenko, L. V., Dotsenko, E. A. and Palii, A. P. (2020b) ‘Study of the toxicity and effectiveness of an antiparasitic agent based on tinidazole and fenbendazole’, Ukrainian Journal of Ecology, 10(6), pp. 272–279. doi: 10.15421/2020_293.

Paliy, A. P., Mashkey, A. N., Faly, L. I., Kysterna, O. S., Rebenko, H. I. and Palii, A. P. (2021a) ‘Ecology of zoophilic flies in livestock biocenoses of Ukraine’, Biosystems Diversity, 29(3), pp. 258–263. doi: 10.15421/012132.

Paliy, A. P., Petrov, R. V., Kovalenko, L. M., Livoshchenko, L. P., Livoshchenko, Y. M., Klishchova, Z. E., Bula, L. V., Ostapenko, V. I., Doletskyi, S. P. and Palii, A. P. (2021b) ‘Effectiveness of a modern antiparasitic agent for deworming in domestic animals’, Ukrainian Journal of Ecology, 11(1), pp. 11–17. Available at: https://www.ujecology.com/abstract/effectiveness-of-a-modern-antiparasitic-agent-for-deworming-in-domestic-animals-62841.html.

Paliy, A. P., Sumakova, N. V., Biben, I. A., Zazharskyi, V. V., Sliusarenko, D. V., Yevtushenko, I. D., Pavlichenko, O. V., Livoshchenko, Y. M., Bulavina, V. S. and Palii, A. P. (2021c) ‘Antihelminthic effects of active substances moxidectin and praziquantel’, Ukrainian Journal of Ecology, 11(3), pp. 248–255. Available at: https://www.ujecology.com/abstract/antihelminthic-effects-of-active-substances-moxidectin-and-praziquantel-78719.html.

Ramünke, S., de Almeida Borges, F., von Son-de Fernex, E., von Samson-Himmelstjerna, G. and Krücken, J. (2018) ‘Molecular marker sequences of cattle Cooperia species identify Cooperia spatulata as a morphotype of Cooperia punctata’, PLoS ONE, 13(7), p. e0200390. doi: 10.1371/journal.pone.0200390.

Seifu, A., Kebede, E., Bacha, B., Melaku, A. and Setegn, T. (2019) ‘Quality of albendazole tablets legally circulating in the pharmaceutical market of Addis Ababa, Ethiopia: Physicochemical evaluation’, BMC Pharmacology and Toxicology, 20(1), p. 20. doi: 10.1186/s40360-019-0299-5.

Shahbazi, A, Fallah, E., Koshki, M. H. K., Nematollahi, A., Ghazanchaei, A. and Asfaram, S. (2012) ‘Morphological characterization of the Trichostrongylus species isolated from sheep in Tabriz, Iran’, Research Opinions in Animal and Veterinary Sciences, 2(5), pp. 309–312. Available at: http://www.roavs.com/pdf-files/Issue_5_2012/309-312.pdf.

Simmonds, R. C. (2017) ‘Chapter 4. Bioethics and animal use in programs of research, teaching, and testing’, in Weichbrod, R. H., Thompson, G. A. and Norton, J. N. (eds.) Management of Animal Care and Use Programs in Research, Education, and Testing. 2nd ed. Boca Raton: CRC Press, pp. 35–62. doi: 10.1201/9781315152189-4.

Takeuchi-Storm, N., Moakes, S., Thüer, S., Grovermann, C., Verwer, C., Verkaik, J., Knubben-Schweizer, G., Höglund, J., Petkevičius, S., Thamsborg, S. and Werne, S. (2019) ‘Parasite control in organic cattle farming: Management and farmers’ perspectives from six European countries’, Veterinary Parasitology: Regional Studies and Reports, 18, p. 100329. doi: 10.1016/j.vprsr.2019.100329.

Taylor, M. A. (2012) ‘Emerging parasitic diseases of sheep’, Veterinary Parasitology, 189(1), pp. 2–7. doi: 10.1016/j.vetpar.2012.03.027.

Thamsborg, S. M., Roepstorff, A., Nejsum, P. and Mejer, H. (2010) ‘Alternative approaches to control of parasites in livestock: Nordic and Baltic perspectives’, Acta Veterinaria Scandinavica, 52(S1), p. S27. doi: 10.1186/1751-0147-52-S1-S27.

Vasil’kova, Z. G. (1955) Methods of Helminthological Research [Metody gel'mintologicheskikh issledovaniy]. Moscow: Medgiz. [in Russian].

Verheyden, H., Richomme, C., Sevila, J., Merlet, J., Lourtet, B., Chaval, Y. and Hoste, H. (2020) ‘Relationship between the excretion of eggs of parasitic helminths in roe deer and local livestock density’, Journal of Helminthology, 94, p. e159. doi: 10.1017/S0022149X20000449.

VRU (Verkhovna Rada Ukrainy) (2006) ‘Law of Ukraine No. 3447-IV of 21.02.2006About protection of animals from cruel treatment’ [Zakon Ukrainy № 3447-IV vid 21.02.2006 ‘Pro zakhyst tvaryn vid zhorstokoho povodzhennia’], News of the Verkhovna Rada of Ukraine [Vidomosti Verkhovnoi Rady Ukrainy], 27, art. 230. Available at: https://zakon.rada.gov.ua/laws/3447-15. [in Ukrainian].