Journal for Veterinary Medicine, Biotechnology and Biosafety

Volume 8, Issue 1–2, May 2022, Pages 3–11

ISSN 2411-3174 (print version) ISSN 2411-0388 (online version)


Paliy A. P. 1, Dotsenko K. A. 1, Pavlichenko O. V. 2, Palii A. P. 2, Rodionova K. O. 3

1 National Scientific Center ‘Institute of Experimental and Clinical Veterinary Medicine’, Kharkiv, Ukraine, e-mail:

2 State Biotechnological University, Kharkiv, Ukraine

3 Odesa State Agrarian University, Odesa, Ukraine

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Citation for print version: Paliy, A. P., Dotsenko, K. A., Pavlichenko, O. V., Palii, A. P. and Rodionova, K. O. (2022) ‘Correction of the sexual function in domestic animals by megestrol acetate’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 8(1–2), pp. 3–11.

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Citation for online version: Paliy, A. P., Dotsenko, K. A., Pavlichenko, O. V., Palii, A. P. and Rodionova, K. O. (2022) ‘Correction of the sexual function in domestic animals by megestrol acetate’, Journal for Veterinary Medicine, Biotechnology and Biosafety. [Online] 8(1–2), pp. 3–11. DOI: 10.36016/JVMBBS-2022-8-1-2-1.

Summary. Correction of sexual function in animals is a topical issue today, despite a large amount of scientific data on this problem. The study aimed to scientifically substantiate the effectiveness of hormonal veterinary drugs in cats and dogs of different breeds and genders. Veterinary drugs with the active substance megestrol acetate were used in the experiments. The studies were performed on clinically healthy cats and dogs of both sexes, different breeds, and ages vaccinated against infectious diseases and treated with antiparasitic drugs. The study was conducted according to the current regulatory documentation. It has been found that the use of hormonal drugs to interrupt/delay estrus in female cats at a dose of 5 mg of megestrol acetate for 8 days leads to a significant decrease in follicle-stimulating hormone, and the content of luteinizing hormone in the blood of cats in the experimental groups reliably decreased throughout the experiment. The use of contraceptives based on megestrol acetate in doses of 2.5 mg for 14 days for cats leads to a reliable decrease in the concentration of testosterone in the serum. It was found that the use of experimental hormonal drugs for female dogs in doses of 5 mg of megestrol acetate per 2.5 kg of body weight in the first 3 days, and half the daily dose from the 4th to the 10th day, leads to a reliable decrease in concentrations of follicle-stimulating and luteinizing hormones in serum compared to the control. Oral administration of experimental hormonal drugs to male dogs in doses of 5 mg of megestrol acetate per 2.5 kg of body weight for 8 days, led to a reliable decrease in the concentration of testosterone in the serum of males. It was found that the estrous cycle in female cats and dogs of the experimental groups after the cessation of hormonal drugs was completely restored, which indicates the safety of drugs with an active ingredient megestrol acetate

Keywords: dogs, cats, hormonal drugs


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