jvmbbs

Issue 2

Journal for Veterinary Medicine, Biotechnology and Biosafety

Volume 3, Issue 2, June 2017, Pages 10–13

ISSN 2411-3174 (print version) ISSN 2411-0388 (online version)

CLINICAL AND BIOCHEMICAL ASPECTS OF DIAGNOSTICS OF OSTEODYSTROPHY OF GOATS

Maslak Yu., Miroshnikova O., Fesenko I.

Kharkiv State Zooveterinary Academy, Kharkiv, Ukraine, e-mail: zemlanoy1980@gmail.com

Citation for print version: Maslak, Yu., Miroshnikova, O. and Fesenko, I. (2017) ‘Clinical and biochemical aspects of diagnostics of Osteodystrophy of goats’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 3(2), pp. 10–13.

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Citation for online version: Maslak, Yu., Miroshnikova, O. and Fesenko, I. (2017) ‘Clinical and biochemical aspects of diagnostics of Osteodystrophy of goats’, Journal for Veterinary Medicine, Biotechnology and Biosafety. [Online] 3(2), pp. 10–13. Available at: http://jvmbbs.kharkov.ua/archive/2017/volume3/issue2/oJVMBBS_2017032_010-013.pdf

Summary. The purpose of this study was to carry out the comparative analysis of data of the clinical examination of goats and biochemical testing of bone tissue metabolism of the metabolites level in blood serum and urine for determination of criteria at diagnostics of osteodystrophy. The study was conducted on 20 adult goats. Diagnosis for osteodystrophy was made according to physical examination of goats and analysis of biochemical tests of bone tissue metabolism using blood serum and urine. Activity of aminotransferase (alanine aminotransferase, aspartate aminotransferase) and alkaline phosphatase and also concentration of glycoproteins (GP), chondroitin sulphate and fractional content of glucosaminoglicans content of total and ionized calcium were determined in blood serum. The content of hydroxyproline and total uronic acid were defined in urine. Comparative analysis of total clinical status of goats and level of biochemical components in blood serum and urine that characterize the connective tissue status at diagnostics of osteodystrophy was conducted. The intergroup significant differences of some biochemical parameters (aspartate aminotransferase, alkaline phisphatase, chondroitin sulphate in blood serum and fraction IІ mucopolysaccharides, sum of fractions glucosaminoglicans in urine) were observed. Further testing must be conducted to determine the biochemical parameters in goat with subclinical signs of osteodystrophy.

Keywords: osteodystrophy, biochemical parameters, goats, blood serum, urine

References:

Borovkov, S. B. (2006) Clinical-biochemical indexes of the state of connecting tissue in diagnostics and treatment of osteodystrophy in cows [Kliniko-biokhimichni pokaznyky stanu spoluchnoi tkanyny v diahnostytsi ta likuvanni osteodystrofii koriv]. The dissertation thesis for the scientific degree of the candidate of veterinary sciences. Bila Tserkva: Bila Tserkva State Agrarian University. Available at: http://www.irbis-nbuv.gov.ua/cgi-bin/irbis_nbuv/cgiirbis_64.exe?C21COM=2&I21DBN=ARD&P21DBN=ARD&Z21ID=&IMAGE_FILE_DOWNLOAD=1&Image_file_name=DOC/2006/06bsblok.zip. [in Ukrainian]

Carstanjen B, Hoyle, N. R., Gabriel, A., Hars, O., Sandersen, C., Amory, H. and Remy, B. (2004) ‘Evaluation of plasma carboxy-terminal cross-linking telopeptide of type I collagen concentration in horses’, American Journal of Veterinary Research, 65(1), pp. 104–109. http://dx.doi.org/10.2460/ajvr.2004.65.104

Cruz, L. A., Lima, M. S. and Peleteiro, M. C. (2002) ‘Osteodystrophia fibrosa in milking goats: report of a clinical case’ [Osteodistrofia fibrosa em cabras de leite: descrição de um caso clínico], Revista Portuguesa de Ciências Veterinárias, 97(543), pp. 147-150. Available at: http://www.fmv.ulisboa.pt/spcv/PDF/pdf9_2002/08_rpcv543.pdf. [in Portuguese]

Di Ferrante, N. and Rich, C. (1956) ‘The determination of acid aminopolysaccharides in urine’, The Journal of Laboratory and Clinical Medicine, 48(3), pp. 491-494. PMID: 13367587

Kamyshnikov, V. S. (2000) Handbook of clinical and biochemical laboratory diagnostics. Volume 2 [Spravochnik po kliniko-biokhimicheskoy laboratornoy diagnostike. Tom 2]. Minsk: Belarus’. ISBN: 9850104449

Kondrakhin, I. P. (1989) Alimentary and endocrine diseases of animals [Alimentarnye i endokrinnye bolezni zhivotnykh]. Moscow: Agropromizdat. ISBN: 5100006471

Krel’, A. A. and Furtseva, L. N. (1968) ‘Methods of determining hydroxyproline in biological fluids and their use in clinical practice’ [Metody opredeleniia oksprolina v biologicheskikh zhidkostiakh i ikh primenenie v klinicheskoĭ praktike], Problems of Medical Chemistry [Voprosy meditsinskoy khimii], 14(6), pp. 635–640. Available at: http://pbmc.ibmc.msk.ru/index.php/ru/article/PBMC-1968-14-6-635-ru. [in Russian]

Liesegang, A., Risteli, J. and Wanner, M. (2007) ‘Bone metabolism of milk goats and sheep during second pregnancy and lactation in comparison to first lactation’, Journal of Animal Physiology and Animal Nutrition, 91(5–6), pp. 217–225. http://dx.doi.org/10.1111/j.1439-0396.2007.00695.x

Shtern, M. R., Timoshenko, O. P., Leont’eva, F. S. and Klyueva, G. F. (1982) Method for determination of hexosaminoglycansulphates in blood serum [Sposob opredeleniya geksozaminoglikansul’fatov v syvorotke krovi]. Author’s Certificate SU 960626. Available at: http://patents.su/3-960626-sposob-opredeleniya-glikozaminglikansulfatov-v-syvorotke-krovi.html

Shteynberg, S. Ya. and Dotsenko, Ya. N. (1962) ‘New method for determination of glycoproteins in serum and blood plasma’ [Novyy metod opredeleniya glikoproteidov v syvorotke i plazme krovi], Medical Practice [Vrachebnoe delo], 12, pp. 43–45

Timoshenko, O. P. and Maslak, Yu. V. (2008) ‘Biochemical indicators in blood serum in healthy goats’ [Biokhimichni pokaznyky u syrovattsi krovi zdorovykh kiz], Collection of Scientific Works of the Luhansk National Agrarian University. Series ‘Veterinary Sciences’ [Zbirnyk naukovykh prats Luhanskoho natsionalnoho ahrarnoho universytetu], 92, pp. 223–226