Issue 4
Journal for Veterinary Medicine, Biotechnology and Biosafety
Volume
4, Issue 4, December 2018, Pages 29–32
ISSN 2411-3174 (print version) ISSN 2411-0388
(online version)
RESEARCH OF TOXICITY
PARAMETERS OF DISINFECTANT ‘SUN STIM’
Kovalenko I. V. 1, Fotina T. I. 2, Fotina H. A. 2, Berezovskyi A. V. 2, Kovalenko V. L. 3, Fotin A. I. 2, Fotin O. V. 2
1 National Scientific Center ‘Institute of
Experimental and Clinical Veterinary Medicine’, Kharkiv, Ukraine,
е-mail: subotairen@gmail.com
2 Sumy National Agrarian University, Sumy,
Ukraine, e-mail: tif_ua@meta.ua
3 State Scientific Control Institute of
Biotechnology and Strains of Microorganisms, Kyiv, Ukraine, e-mail: kovalenkodoktor@gmail.com
Download
PDF (print version)
Citation for print version: Kovalenko, I. V.,
Fotina, T. I., Fotina, H. A.,
Berezovskyi, A. V., Kovalenko, V. L.,
Fotin, A. I. and Fotin, O. V.
(2018) ‘Research of toxicity parameters of disinfectant ‘Sun Stim’’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 4(4),
pp. 29–32.
Download
PDF (online version)
Citation for online version: Kovalenko, I. V.,
Fotina, T. I., Fotina, H. A.,
Berezovskyi, A. V., Kovalenko, V. L.,
Fotin, A. I. and Fotin, O. V.
(2018) ‘Research of toxicity parameters of disinfectant ‘Sun Stim’, Journal
for Veterinary Medicine, Biotechnology and Biosafety.
[Online] 4(4), pp. 29–32. Available at: http://jvmbbs.kharkov.ua/archive/2018/volume4/issue4/oJVMBBS_2018044_029-032.pdf
Summary. Acute toxicity of set ‘Sun Stim’ was determined on laboratory animals in an
experimental laboratory research. The disinfectant has high biological activity
and low toxicity due to the active substance which is
able to show a broad spectrum of activity against microorganisms. Based on the
results, DL50 of the set for sanitation
‘Sun Stim’ for female rats
2,000.0 ± 35.0 mg/kg body weight, male —
2,033.0 ± 34.3 mg/kg. Thus, this drug, when injected into
the stomach, according to the classification of toxicity in accordance with state
standard (GOSТ 12.1.007-76), is allowed to be
classified as III hazard class, low-hazard compounds. The set for sanitation
‘Sun Stim’ and the substances from which
it was made do not have carcinogenic, mutagenic or genotoxic effects.
Keywords: ‘Sun Stim’,
PGMG (polyhexamethylene
guanidine hydrochloride), acute toxicity, laboratory animals, disinfectant
References:
Addie, D. D.,
Boucraut-Baralon, C., Egberink, H.,
Frymus, T., Gruffydd-Jones, T.,
Hartmann, K., Horzinek, M. C., Hosie, M. J., Lloret, A.,
Lutz, H., Marsilio, F., Pennisi, M. G.,
Radford, A. D., Thiry, E., Truyen, U. and Möstl, K.
(2015) ‘Disinfectant choices in veterinary practices, shelters and
households: ABCD guidelines on safe and effective
disinfection for feline environments’, Journal of Feline Medicine and
Surgery, 17(7), pp. 594–605. http://dx.doi.org/10.1177/1098612X15588450
Buckmaster, C. (2012) ‘Shifting the culture
of lab animal care’, Lab Animal (NY), 41(7), p. 205. http://dx.doi.org/10.1038/laban0712-205
CEC (The Council of the European
Communities). (1986) ‘Council
Directive 86/609/EEC of 24 November 1986 on the approximation of laws,
regulations and administrative provisions of the Member States regarding the
protection of animals used for experimental and other scientific purposes’,
The Official Journal of the European Communities, L 358, pp. 1–28.
Available at: http://data.europa.eu/eli/dir/1986/609/oj
GOST 12.1.007-76. Occupational safety
standards system. Noxious substances. Classification and general safety
requirements [Sistema standartov bezopasnosti
truda. Vrednye veshchestva. Klassifikatsiya i obshchie trebovaniya
bezopasnosti]. [in
Russian]
Kalyn, P. S. (2009) Comparative
assessment of incubation eggs decontamination agent’s efficiency [Porivnialna otsinka efektyvnosti zasobiv dekontaminatsii inkubatsiinykh yaiets]. The dissertation thesis for the scientific
degree of the candidate of veterinary sciences. Kharkiv: National Scientific
Center ‘Institute of Experimental and Clinical Veterinary Medicine’.
[in Ukrainian]
Kim, H.-R., Hwang, G.-W., Naganuma, A. and Chung, K.-H. (2016) ‘Adverse
health effects of humidifier disinfectants in Korea: lung toxicity of polyhexamethylene guanidine phosphate’, The
Journal of Toxicological Sciences, 41(6), pp. 711–717. http://dx.doi.org/10.2131/jts.41.711
Kosenko, M. V., Malyk, O. H.,
Kotsiumbas, I. Ya.,
Patereha, I. P. and Chura, D. O.
(1997) Toxicological control of new means of animal protection:
methodological recommendations [Toksykolohichnyi kontrol novykh zasobiv zakhystu tvaryn: metodychni rekomendatsii]. Kyiv. [in Ukrainian]
Kotsiumbas, I. Ya., Malyk, O. H.,
Patereha, I. P., Tishyn, O. L.
and Kosenko, Yu. M. (2006) Preclinical
studies of veterinary drugs [Doklinichni doslidzhennia veterynarnykh likarskykh zasobiv]. Lviv: Triada plus. ISBN 9667596648. [in Ukrainian]
Kovalenko, V. L. (2011) ‘Determination
of bactericidality of a complex disinfectant based on
polyhexamethylene guanidine hydrochloride’ [Vyznachennia bakterytsydnosti kompleksnoho dezinfikuiuchoho preparatu na
osnovi poliheksametylenhuanidyn
hidrokhlorydu], Veterinary Biotechnology [Veterynarna biotekhnolohiia],
18, pp. 65–70. [in Ukrainian]
Kovalenko, V. L. and Nedosiekov, V. V.
(eds.) (2011) Concept of development and use of complex disinfectants for
veterinary medicine [Kontseptsiia rozrobky
ta vykorystannia kompleksnykh
dezinfektantiv dlia veterynarnoi medytsyny].
Kyiv: NUBiP Ukrainy. [in Ukrainian]
Kovalenko, V. L., Kovalenko, P. L.,
Ponomarenko, G. V., Kukhtyn, M. D.,
Midyk, S. V., Horiuk, Yu. V.
and Garkavenko, V. M. (2018) ‘Changes
in lipid composition of Escherichia coli and Staphylococcus aureus cells under the influence of disinfectants Barez®, Biochlor®
and Geocide®’, Ukrainian
Journal of Ecology, 8(1), pp. 547–550. http://dx.doi.org/10.15421/2018_248
Kovalenko, V. L., Yashchenko, M. F.,
Chekhun, A. I. and Rezunenko, Ye. V.
(2009) ‘Study of physical and chemical properties of combined
disinfectants’ [Vyvchennia fizyko-khimichnykh
vlastyvostei kombinovanykh dezinfektantiv], Problems of Zooengineering
and Veterinary Medicine [Problemy zooinzhenerii
ta veterynarnoi medytsyny],
19(2.3), pp. 195–199. [in Ukrainian]
Kovalenko, V. L., Zasiekin, D. A.,
Nedosiekov, V. V., Nychyk, S. A.
and Hnatenko, A. V. (2013) Development
and control of disinfectant [Rozrobka i kontrol dezinfikuiuchoho
zasobu]. Kyiv: Interservis.
ISBN 978966245307. [in Ukrainian]
Lysytsya, A. V., Маndygra, Y. M.,
Bоjko, О. P., Rоmanishyna, О. O. and Маndygra, M. S. (2015)
‘Differential sensitivity of microorganisms to polyhexamethyleneguanidine’
[Dyferentsiina chutlyvist mikroorhanizmiv do poliheksametylenhuanidynu],
Microbiological Journal [Mikrobiolohichnyi Zhurnal], 77(5), pp. 11–19. http://dx.doi.org/10.15407/microbiolj77.05.011.
[in Ukrainian]
Mandyhra, M. S., Stepaniak, I.
V., Lysytsia, A. V. and Mandyhra, Yu. M. (2008) ‘Use of polyhexamethylene
guanidine for disinfection’ [Vykorystannia
poliheksametylenhuanidynu dlia
dezinfektsii],
Agrarian News of Prychornomoria. Veterinary
Sciences [Ahrarnyi visnyk Prychornomoria. Veterynarni nauky], 42(2), pp. 69–73. [in Ukrainian]
Souza, A. L., Ceridório, L. F.,
Paula, G. F., Mattoso, L. H. C.
and Oliveira, O. N. (2015) ‘Understanding the biocide action of
poly(hexamethylene biguanide)
using Langmuir monolayers of dipalmitoyl phosphatidylglycerol’, Colloids and Surfaces B:
Biointerfaces, 132, pp. 117–121. http://dx.doi.org/10.1016/j.colsurfb.2015.05.018