Journal for Veterinary Medicine, Biotechnology and Biosafety
Volume
8, Issue 1–2, May 2022, Pages 3–11
ISSN 2411-3174 (print version) ISSN 2411-0388
(online version)
CORRECTION OF THE SEXUAL
FUNCTION IN DOMESTIC ANIMALS BY MEGESTROL ACETATE
Paliy A. P. 1,
Dotsenko K. A. 1, Pavlichenko O. V. 2,
Palii A. P. 2, Rodionova K. O. 3
1 National
Scientific Center ‘Institute of Experimental and Clinical Veterinary
Medicine’, Kharkiv, Ukraine, e-mail: paliy.dok@gmail.com
2 State
Biotechnological University, Kharkiv, Ukraine
3 Odesa State
Agrarian University, Odesa, Ukraine
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PDF (print version)
Citation for print version: Paliy, A. P., Dotsenko, K. A.,
Pavlichenko, O. V., Palii, A. P. and Rodionova, K. O.
(2022) ‘Correction of the sexual function in domestic animals by
megestrol acetate’, Journal
for Veterinary Medicine, Biotechnology and Biosafety, 8(1–2),
pp. 3–11.
Download
PDF (online version)
Citation for online version: Paliy, A. P., Dotsenko, K. A.,
Pavlichenko, O. V., Palii, A. P. and Rodionova, K. O.
(2022) ‘Correction of the sexual function in domestic animals by
megestrol acetate’, Journal
for Veterinary Medicine, Biotechnology and Biosafety.
[Online] 8(1–2), pp. 3–11. DOI: 10.36016/JVMBBS-2022-8-1-2-1.
Summary. Correction of sexual function in animals is a
topical issue today, despite a large amount of scientific data on this problem.
The study aimed to scientifically substantiate the effectiveness of hormonal
veterinary drugs in cats and dogs of different breeds and genders. Veterinary
drugs with the active substance megestrol acetate were used in the experiments.
The studies were performed on clinically healthy cats and dogs of both sexes,
different breeds, and ages vaccinated against infectious diseases and treated
with antiparasitic drugs. The study was conducted according to the current
regulatory documentation. It has been found that the use of hormonal drugs to
interrupt/delay estrus in female cats at a dose of 5 mg of megestrol
acetate for 8 days leads to a significant decrease in follicle-stimulating
hormone, and the content of luteinizing hormone in the blood of cats in the
experimental groups reliably decreased throughout the experiment. The use of
contraceptives based on megestrol acetate in doses of 2.5 mg for
14 days for cats leads to a reliable decrease in the concentration of
testosterone in the serum. It was found that the use of experimental hormonal
drugs for female dogs in doses of 5 mg of megestrol acetate per
2.5 kg of body weight in the first 3 days, and half the daily dose
from the 4th to the 10th day, leads to a reliable
decrease in concentrations of follicle-stimulating and luteinizing hormones in
serum compared to the control. Oral administration of experimental hormonal
drugs to male dogs in doses of 5 mg of megestrol acetate per 2.5 kg
of body weight for 8 days, led to a reliable decrease in the concentration
of testosterone in the serum of males. It was found that the estrous cycle in
female cats and dogs of the experimental groups after the cessation of hormonal
drugs was completely restored, which indicates the safety of drugs with an
active ingredient megestrol acetate
Keywords: dogs, cats, hormonal drugs
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