Journal for Veterinary Medicine, Biotechnology and Biosafety
Volume
10, Issue 1, March 2024, Pages 3–6
ISSN 2411-3174 (print version) ISSN 2411-0388
(online version)
THE ROLE OF ACUTE PHASE INFLAMMATORY
PROTEINS IN THE PATHOGENESIS OF METABOLIC SYNDROME IN OBESE HORSES
Borovkov S. B., Boiko V. S.
National Scientific
Center ‘Institute of Experimental and Clinical Veterinary
Medicine’, Kharkiv, Ukraine, e-mail: serg_b78@ukr.net
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PDF (print version)
Citation for print version: Borovkov, S. B.
and Boiko, V. S. (2024) ‘The
role of acute phase inflammatory proteins in the pathogenesis of Metabolic syndrome
in obese horses’, Journal
for Veterinary Medicine, Biotechnology and Biosafety, 10(1),
pp. 3–6.
Download
PDF (online version)
Citation for online version: Borovkov, S. B.
and Boiko, V. S. (2024) ‘The
role of acute phase inflammatory proteins in the pathogenesis of Metabolic syndrome in obese horses’, Journal for Veterinary Medicine, Biotechnology and
Biosafety. [Online] 10(1), pp. 3–6. DOI: 10.36016/JVMBBS-2024-10-1-1.
Summary. Metabolic syndrome and obesity in horses are
closely related processes that are accompanied by
chronic inflammation. Our research aimed to establish the normative indicators
of acute phase inflammation proteins in obese horses. We conducted a study on
twenty horses, ten of which were in the control group and ten were in the
experimental group, showing signs of obesity. The Henneke
scoring system was used to assess the body condition.
This system ranks animals from one to nine, with one being
exhausted and nine being very fat. Serum concentrations of circulating
immune complexes, seromucoids, C-reactive protein, haptoglobin, total protein, and its fractions were
determined. It was found that significant changes in
protein metabolism occur in animals with obesity, namely: the content of
circulating immune complexes, seromucoids, C-reactive
protein, haptoglobin, and globulins significantly
increase, indicating the development of inflammatory processes in horses due to
obesity. The localization of these processes is associated both with obesity in
animals and possibly with laminitis, the development of which is one of the pathogenetic links of metabolic syndrome
Keywords: laminitis, blood
serum, protein metabolism
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