Journal for Veterinary Medicine, Biotechnology and Biosafety

Volume 10, Issue 1, March 2024, Pages 3–6

ISSN 2411-3174 (print version) ISSN 2411-0388 (online version)

THE ROLE OF ACUTE PHASE INFLAMMATORY PROTEINS IN THE PATHOGENESIS OF METABOLIC SYNDROME IN OBESE HORSES

Borovkov S. B., Boiko V. S.

National Scientific Center ‘Institute of Experimental and Clinical Veterinary Medicine’, Kharkiv, Ukraine, e-mail: serg_b78@ukr.net

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Citation for print version: Borovkov, S. B. and Boiko, V. S. (2024) ‘The role of acute phase inflammatory proteins in the pathogenesis of Metabolic syndrome in obese horses’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 10(1), pp. 3–6.

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Citation for online version: Borovkov, S. B. and Boiko, V. S. (2024) ‘The role of acute phase inflammatory proteins in the pathogenesis of Metabolic syndrome in obese horses’, Journal for Veterinary Medicine, Biotechnology and Biosafety. [Online] 10(1), pp. 3–6. DOI: 10.36016/JVMBBS-2024-10-1-1.

Summary. Metabolic syndrome and obesity in horses are closely related processes that are accompanied by chronic inflammation. Our research aimed to establish the normative indicators of acute phase inflammation proteins in obese horses. We conducted a study on twenty horses, ten of which were in the control group and ten were in the experimental group, showing signs of obesity. The Henneke scoring system was used to assess the body condition. This system ranks animals from one to nine, with one being exhausted and nine being very fat. Serum concentrations of circulating immune complexes, seromucoids, C-reactive protein, haptoglobin, total protein, and its fractions were determined. It was found that significant changes in protein metabolism occur in animals with obesity, namely: the content of circulating immune complexes, seromucoids, C-reactive protein, haptoglobin, and globulins significantly increase, indicating the development of inflammatory processes in horses due to obesity. The localization of these processes is associated both with obesity in animals and possibly with laminitis, the development of which is one of the pathogenetic links of metabolic syndrome

Keywords: laminitis, blood serum, protein metabolism

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