Journal for Veterinary Medicine, Biotechnology and Biosafety

Volume 10, Issue 4, October 2024, Pages 28–32

ISSN 2411-3174 (print version) ISSN 2411-0388 (online version)

POTENTIATION OF ACARICIDAL DRUGS WITH THE HELP OF A PHYTOCOMPLEX THAT UNDERGOES CRYODESTRUCTION

Kiptenko A. V., Dunaiev Yu. K., Paliy A. P., Bogach M. V., Keleberda M. I.

National Scientific Center ‘Institute of Experimental and Clinical Veterinary Medicine’, Kharkiv, Ukraine, e-mail: bogach_nv@ukr.net

Download PDF (print version)

Citation for print version: Kiptenko, A. V., Dunaiev, Yu. K., Paliy, A. P., Bogach, M. V. and Keleberda, M. I. (2024) ‘Potentiation of acaricidal drugs with the help of a phytocomplex that undergoes cryodestruction’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 10(4), pp. 28–32.

Download PDF (online version)

Citation for online version: Kiptenko, A. V., Dunaiev, Yu. K., Paliy, A. P., Bogach, M. V. and Keleberda, M. I. (2024) ‘Potentiation of acaricidal drugs with the help of a phytocomplex that undergoes cryodestruction’, Journal for Veterinary Medicine, Biotechnology and Biosafety. [Online] 10(4), pp. 28–32. DOI: 10.36016/JVMBBS-2024-10-4-4.

Summary. The objective of this study was to develop a novel natural veterinary pharmaceutical agent for the treatment of tick and mite infections, with the aim of experimentally confirming its efficacy in vivo. The dogs selected for the experiment were divided into three groups (n = 27) according to the type of tick infection, with each group divided into three subgroups (n = 9). The first experimental group of dogs was affected by ixodid ticks, the second by sarcoptic mites, and the third by thrombidiform mites. The groups were then subdivided into three smaller groups. Group I received treatment with ‘AnimAll VetLine’ antiparasitic tablets for dogs and cats, Group II received treatment with ‘Acaro Spectra’ antiparasitic tablets for dogs, and Group III served as the control group, whose condition was monitored without treatment. The antiparasitic tablets, designated ‘Acaro Spectra’, demonstrated efficacy within 24 hours. The test results indicated that the ticks were removed within the same timeframe, and no new ticks attached. Additionally, the administration of ‘Acaro Spectra’ did not elicit any allergic reactions or signs of distress in the animals. In the treatment of dogs affected by ixodid ticks, sarcoptic, and thrombidiform mites, the drug ‘Acaro Spectra’ antiparasitic tablets for dogs showed 100% effectiveness. The results obtained allow us to recommend the drug ‘Acaro Spectra’ antiparasitic tablets for dogs for the treatment and prevention of ixodid ticks (Ixodes ricinus, Rhipicephalus sanguineus, Dermacentor reticulatus), sarcoptic mites (Otodectes cynotis, Notoedres cati, Sarcoptes canis), thrombidiform mites (Demodex spp., Cheyletiella spp.)

Keywords: ixodid ticks, sarcoptic mites, thrombidiform mites, treatment

References:

Aguilar-Meraz, P., Moo-Llanes, D. A., Sánchez-Montes, S., Montes De Oca-Aguilar, A. C., Romero-Salas, D., Cruz-Romero, A., López-Hernández, K. M., Bermúdez-Castillero, S. E. and Aguilar-Domínguez, M. (2024) ‘Effect of an altitudinal gradient on the morphology, molecular identification and distribution of Rhipicephalus linnaei in Veracruz, Mexico’, Acta Tropica, 252, p. 107135. doi: 10.1016/j.actatropica.2024.107135.

Bebrysz, M., Wright, A., Greaves, M., Rathwell Deault, D., Hopkins, G., Gildea, E. and Aballéa, S. (2021) ‘How pet owners choose antiparasitic treatments for their dogs: A discrete choice experiment’, Preventive Veterinary Medicine, 196, p. 105493. doi: 10.1016/j.prevetmed.2021.105493.

Beck, W., Boch, K., Mackensen, H., Wiegand, B. and Pfister, K. (2006) ‘Qualitative and quantitative observations on the flea population dynamics of dogs and cats in several areas of Germany’, Veterinary Parasitology, 137(1–2), pp. 130–136. doi: 10.1016/j.vetpar.2005.12.021.

Bharadwaj, A., Hayes, L. E. and Stafford, K. C. (2015) ‘Effectiveness of garlic for the control of Ixodes scapularis (Acari: Ixodidae) on residential properties in Western Connecticut’, Journal of Medical Entomology, 52(4), pp. 722–725. doi: 10.1093/jme/tjv044.

Boost, M. V., Tung, C., Ip, C. H.-K., Man, J. F., Hui, T. W., Leung, C. F., Mak, M. Y., Yuen, Q. and O’Donoghue, M. M. (2017) ‘Awareness of tick-borne disease and compliance with using tick preventive products of dog owners in Hong Kong’, Preventive Veterinary Medicine, 137, pp. 97–100. doi: 10.1016/j.prevetmed.2016.12.010.

Estrada-Peña, A., Roura, X., Sainz, A., Miró, G. and Solano-Gallego, L. (2017) ‘Species of ticks and carried pathogens in owned dogs in Spain: Results of a one-year national survey’, Ticks and Tick-borne Diseases, 8(4), pp. 443–452. doi: 10.1016/j.ttbdis.2017.02.001.

Geurden, T., Smith, E. R., Vercruysse, J., Yazwinski, T., Settje, T. and Nielsen, M. K. (2022) ‘World Association for the Advancement of Veterinary Parasitology (WAAVP) guideline for the evaluation of the efficacy of anthelmintics in food-producing and companion animals: general guidelines’, Veterinary Parasitology, 304, p. 109698. doi: 10.1016/j.vetpar.2022.109698.

Giannelli, A., Schnyder, M., Wright, I. and Charlier, J. (2024) ‘Control of companion animal parasites and impact on One Health’, One Health, 18, p. 100679. doi: 10.1016/j.onehlt.2024.100679.

Heyman, P., Cochez, C., Hofhuis, A., Van Der Giessen, J., Sprong, H., Porter, S. R., Losson, B., Saegerman, C., Donoso-Mantke, O., Niedrig, M. and Papa, A. (2010) ‘A clear and present danger: tick-borne diseases in Europe’, Expert Review of Anti-infective Therapy, 8(1), pp. 33–50. doi: 10.1586/eri.09.118.

Jacobs, D. E., Arakawa, A., Courtney, C. H., Gemmell, M. A., McCall, J. W., Myers, G. H. and Vanparijs, O. (1994) ‘World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guidelines for evaluating the efficacy of anthelmintics for dogs and cats’, Veterinary Parasitology, 52(3–4), pp. 179–202. doi: 10.1016/0304-4017(94)90110-4.

Kruchynenko, O. V. (2020) ‘Ectoparasites of dogs and cats (spreading and treatment)’ [Ektoparazyty sobak i kotiv (poshyrennia ta likuvannia)], Bulletin of Poltava State Agrarian Academy [Visnyk Poltavskoi derzhavnoi ahrarnoi akademii], 3, pp. 241–250. doi: 10.31210/visnyk2020.03.28. [in Ukrainian].

Lavan, R., Armstrong, R., Burgio, F. and Tunceli, K. (2018) ‘Duration of annual canine flea and tick protection provided by dog owners in Spain’, Parasites & Vectors, 11(1), p. 458. doi: 10.1186/s13071-018-3043-x.

Matos, M., Alho, A. M., Owen, S. P., Nunes, T. and Madeira De Carvalho, L. (2015) ‘Parasite control practices and public perception of parasitic diseases: A survey of dog and cat owners’, Preventive Veterinary Medicine, 122(1–2), pp. 174–180. doi: 10.1016/j.prevetmed.2015.09.006.

Paliy, A. P., Sumakova, N. V., Rodionova, K. O., Mashkey, A. M., Alekseeva, N. V., Losieva, Ye. A., Zaiarko, A. I., Kostyuk, V. K., Dudus, T. V., Morozov, B. S., Hurtovyi, O. O. and Palii, A. P. (2021) ‘Efficacy of flea and tick collars against the ectoparasites of domestic animals’, Ukrainian Journal of Ecology, 11(2), pp. 197–203. Available at: https://www.ujecology.com/articles/efficacy-of-flea-and-tick-collars-against-the-ectoparasites-of-domestic-animals-70487.html.

Paliy, A., Pavlichenko, O., Kasianenko, S., Kovalenko, L., Stockiy, A. and Stotska, O. (2023) ‘Peculiarities of the course of demodicosis in domestic animals in a megalopolis in the east of Ukraine’, Regulatory Mechanisms in Biosystems, 14(1), pp. 28–33. doi: 10.15421/022305.

Paliy, A. P., Sumakova, N. V., Bohach, O. M., Borovkov, S. B., Pavlichenko, O. V., Ihnatieva, T. M. and Dubin, R. A. (2024) ‘Effectiveness of modern antiparasitic animal collars’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 10(1), pp. 33–39. doi: 10.36016/JVMBBS-2024-10-1-6.

Schmahl, G., Al-Rasheid, K. A. S., Abdel-Ghaffar, F., Klimpel, S. and Mehlhorn, H. (2010) ‘The efficacy of neem seed extracts (Tre-san®, MiteStop®) on a broad spectrum of pests and parasites’, Parasitology Research, 107(2), pp. 261–269. doi: 10.1007/s00436-010-1915-x.

Tishyn, O. L., Yuskiv, I. D. and Yuskiv, L. L. (2024) ‘Effectiveness of ivermectin against ecto- and endoparasitic invasion of dogs’ [Efektyvnist ivermektynu proty ekto- ta endoparazytarnykh invazii sobak], Scientific and Technical Bulletin of State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives and Institute of Animal Biology [Naukovo-tekhnichnyi biuleten Derzhavnoho naukovo-doslidnoho kontrolnoho instytutu veterynarnykh preparativ ta kormovykh dobavok i Instytutu biolohii tvaryn], 25(1), pp. 212–223. doi: 10.36359/scivp.2024-25-1.27. [in Ukrainian].