Journal for Veterinary Medicine, Biotechnology and Biosafety
Volume
11, Issue 1, January 2025, Pages 3–9
ISSN 2411-3174 (print version) ISSN 2411-0388
(online version)
DYNAMICS
OF LIPID PEROXIDATION IN OBESE HORSES
Borovkov S. B., Boiko V. S.
National Scientific
Center ‘Institute of Experimental and Clinical Veterinary
Medicine’, Kharkiv, Ukraine, e-mail: serg_b78@ukr.net
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PDF (print version)
Citation for
print version: Borovkov, S. B. and Boiko, V. S.
(2025) ‘Dynamics of lipid
peroxidation in obese horses’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 11(1),
pp. 3–9.
Download
PDF (online version)
Citation for
online version: Borovkov, S. B. and Boiko, V. S.
(2025) ‘Dynamics of lipid
peroxidation in obese horses’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 11(1),
pp. 3–9. DOI: 10.36016/JVMBBS-2025-11-1-1.
Summary. Obesity is a pathological condition characterized by
a specific pathogenetic process involving lipoperoxidation. Laboratory data on the levels of lipid
peroxidation products in biological samples provide insights into the extent
and severity of damage associated with this condition. This study aimed to
investigate the impact of obesity on the intensity of lipid peroxidation
processes as well as the compensatory activity of the antioxidant defense
system in horses following influenza vaccination. In horses exhibiting signs of
obesity, vaccination triggers oxidative stress, which is
marked by excessive production of toxic lipoperoxidation
products, specifically diene conjugates and malondialdehyde. On average, these levels were found to be 16.9% and 17.6% higher
(p < 0.01) compared to those in horses with normal weight. The
development of oxidative stress is regulated by
antioxidant mechanisms, including catalase activity and total antioxidant
activity, both of which were significantly reduced in horses with obesity.
Specifically, these measures were lower by an average of 12.2% and 9.8%
(p < 0.01) in the obese horses compared to their normal-weight
counterparts. Markers of oxidative stress (content of diene
conjugates and malondialdehyde), the activity of
antioxidant defense enzymes, and total antioxidant activity in the blood of
horses after vaccination are sensitive and informative indicators that can be used to assess the impact of vaccine prophylaxis,
especially in animals with signs of obesity. Thus, obesity in horses
significantly affects the levels of lipid peroxidation and oxidative stress,
which can lead to serious health complications. Further research in this area
may help develop effective strategies for preventing and treating obesity in
horses, ultimately improving their overall health. Additionally, this research
could serve as a foundation for future studies on the broader impact of
oxidative stress on animal health
Keywords: metabolic
syndrome, oxidative stress
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