Issue 2
Journal for Veterinary Medicine, Biotechnology and Biosafety
Volume
3, Issue 2, June 2017, Pages 37–44
ISSN 2411-3174 (print version) ISSN 2411-0388
(online version)
ANALYSIS OF SNPS F279Y
AND S555G
IN GROWTH HORMONE RECEPTOR GENE IN BEEF AND DAIRY CATTLE BREEDS
Fedota O. M. 1 ,
Ruban S. Yu. 2 , Lysenko N. G. 1,*,
Goraichuk I. V. 3 , Tyzhnenko
T. V. 1 , Mitioglo L. V. 4 , Dzhus P. P. 5 , Birukova
O. D. 5
1 V. N. Karazin Kharkiv National University, Kharkiv,
Ukraine, e-mail: afedota@mail.ru
2 LLC ‘MPK Ekaterinoslavsky’, Dnipro,
Ukraine
3 National Scientific Center ‘Institute of Experimental and
Clinical Veterinary Medicine’, Kharkiv, Ukraine
4 DP DG ‘Nyva’,
Khrystynivka, Ukraine
5 Institute of Animal Breeding and Genetics
nd. a. M. V. Zubets of NAAS, Chubynske,
Ukraine
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PDF (print version)
Citation for print version: Fedota, O. M., Ruban, S. Yu., Lysenko, N. G., Goraichuk,
I. V., Tyzhnenko, T. V., Mitioglo,
L. V., Dzhus, P. P. and Birukova,
O. D. (2017) ‘Analysis of SNPS F279Y and S555G in growth
hormone receptor gene in beef and dairy cattle breeds’, Journal for Veterinary Medicine, Biotechnology and
Biosafety, 3(2), pp. 37–44.
Download
PDF (online version)
Citation for online version: Fedota, O. M., Ruban, S. Yu., Lysenko, N. G., Goraichuk,
I. V., Tyzhnenko, T. V., Mitioglo,
L. V., Dzhus, P. P. and Birukova,
O. D. (2017) ‘Analysis of SNPS F279Y and S555G in growth
hormone receptor gene in beef and dairy cattle breeds’, Journal for Veterinary Medicine, Biotechnology and
Biosafety. [Online] 3(2), pp. 37–44. Available at:
http://jvmbbs.kharkov.ua/archive/2017/volume3/issue2/oJVMBBS_2017032_037-044.pdf
Summary. Effect
of growth hormone on animal growth and metabolism is mediated
by interaction with the specific receptor (GHR). Marker-assisted selection
programs in cattle include SNPs in GHR gene regarding
their association with fertility and lactation performance. The aim was to analyze
the relation between SNPs F279Y and S555G in GHR
gene with growth traits in Aberdeen-Angus and tp draw comparisons with beef and dairy cattle of other
countries. SNP genotyping was
performed with PCR-RFLP methods. Statistical
methods included Pearson’s chi-squared test, Pearson’s correlation
coefficient r and ANOVA. The allele
and genotype frequencies of SNP F279Y (rs385640152; g. 914T>A)
are: T —
0.69 and A — 0.31; TT — 62.1%,
TA — 13.8% and AA — 24.1% (n = 58); SNP S555G (rs109300983;
g. 257A>G)
are: A — 0.86 and G — 0.14; AA — 73.1%, AG — 25.0% and GG — 1.9%
(n = 58). Population is in Hardy-Weinberg equilibrium for S555G, contrary
to F279Y. Animals
with AA-genotype of SNP F279Y are characterized by the higher ADG (+40–100 g/day), as well as body weight at 8 month
(+10–30 kg) and 2 years (up to +40 kg).
In total dairy breeds group the frequency of T‑allele in SNP F279Y negatively correlated with milk yield (r=–0.713).
Keywords: Aberdeen-Angus
breed, growth hormone receptor gene, SNP F279Y, SNP
S555G
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