Journal for Veterinary Medicine, Biotechnology and Biosafety
Volume
10, Issue 2, June 2024, Pages 7–12
ISSN 2411-3174 (print version) ISSN 2411-0388
(online version)
STUDY THE IMMUNOSTIMULATORY PROPERTIES OF A SOLUTION FOR INJECTION
COMPRISING NATURAL POWDERED HONEY IN LABORATORY ANIMALS
Yemelianov A. V. 1, Koshova O. Yu. 2,
Sumakova N. V. 1, Paliy A. P. 1
1 National
Scientific Center ‘Institute of Experimental and Clinical Veterinary
Medicine’, Kharkiv, Ukraine, e-mail: sumakova1962natali@gmail.com
2 National
University of Pharmacy, Kharkiv, Ukraine
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PDF (print version)
Citation for print version: Yemelianov, A. V.,
Koshova, O. Yu., Sumakova, N. V.
and Paliy, A. P. (2024) ‘Study the immunostimulatory
properties of a solution for injection comprising natural powdered honey in
laboratory animals’, Journal
for Veterinary Medicine, Biotechnology and Biosafety, 10(2),
pp. 7–12.
Download
PDF (online version)
Citation for online version: Yemelianov, A. V.,
Koshova, O. Yu., Sumakova, N. V.
and Paliy, A. P. (2024) ‘Study the immunostimulatory
properties of a solution for injection comprising natural powdered honey in
laboratory animals’, Journal
for Veterinary Medicine, Biotechnology and Biosafety.
[Online] 10(2), pp. 7–12. DOI: 10.36016/JVMBBS-2024-10-2-2.
Summary. The article presents the results of pharmacological
studies of a new domestic drug ‘Apimel’
in the form of a solution for injection based on natural powdered honey as an
active ingredient. The effect of the solution for injections with natural
powdered honey on the severity of the immune response in rats and mice with
normal immune status was studied, and the immunostimulating properties of the drug ‘Apimel’ in mice with immunodeficiency were studied.
It was found that the most pronounced immunostimulatory properties of the drug were observed in
doses of 50 and 250 mg of natural powdered honey/kg body weight. The study
of the effect of the drug on the development of a slow-type hypersensitivity
reaction in mice revealed the anti-inflammatory properties of the drug at doses
of 25 and 150 mg of natural powdered honey per kilogram of body weight. In the course of studying the immunostimulating
properties of the investigated drug in mice with immunodeficiency, it was found
that the solution for injection at a dose of 50 mg of natural powdered
honey/kg body weight restored the processes of antibody formation at the level
of the comparison drug, and significantly exceeded it in terms of the
expression of phagocytic activity of neutrophils
Keywords: immunodeficiency,
phagocytosis, mice, rats
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