• Home
• Archive
• Rules for Authors
• Policies on Conflict of Interest, Human and animal rights, and Informed Consent
• Peer reviewering policy
• Editorial Board
• Certificate
• Editorial Ethics
• Contacts

Journal for Veterinary Medicine, Biotechnology and Biosafety

Volume 10, Issue 2, June 2024, Pages 20–24

ISSN 2411-3174 (print version) ISSN 2411-0388 (online version)

INVESTIGATING THE STABILITY OF A SYMBIOTIC BIOLOGICALLY ACTIVE SUPPLEMENT FOR ANIMALS DURING STORAGE

Gujvinska S. O.

National Scientific Center ‘Institute of Experimental and Clinical Veterinary Medicine’, Kharkiv, Ukraine, e-mail: biotechvet2024@gmail.com

Download PDF (print version)

Citation for print version: Gujvinska, S. O. (2024) ‘Investigating the stability of a symbiotic biologically active supplement for animals during storage’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 10(2), pp. 20–24.

Download PDF (online version)

Citation for online version: Gujvinska, S. O. (2024) ‘Investigating the stability of a symbiotic biologically active supplement for animals during storage’, Journal for Veterinary Medicine, Biotechnology and Biosafety. [Online] 10(2), pp. 20–24. DOI: 10.36016/JVMBBS-2024-10-2-4.

Summary. The aim of this work was to determine the stability of a symbiotic biologically active supplement for animals during storage and to establish its shelf life. The stability of the symbiotic was studied under two temperature conditions. The results obtained indicate that the symbiotic biologically active supplement for animals retained its biochemical activity on the day of manufacture and after 3, 6, 9, 12, 15, 18, 21, and 24 months and was harmless to white mice throughout the study period when stored at a temperature of 4 ± 0.5 °C. The drug remained suitable for use for 3 months after manufacture when stored at room temperature (20 ± 2 °C). Taking into account the results of the experimental data, it is recommended to store the symbiotic in the refrigerator at a temperature of 4 ± 0.5 °C for 24 months and at a temperature of 20 ± 2 °C for 3 months

Keywords: Lactobacillus plantarum No. 7-317, Bifidobacterium adolescentis No. 17-316, quality indicators

References:

AEProbio (Alliance for Education on Probiotics). (2021). Understanding probiotics. Available at: https://www.aeprobio.com/understanding-probiotics.

Cherevan, Y. O., Sidashenko, O. I., Tymchyy, K. I., Fedota, S. V. and Volkov, R. D. (2018) ‘Prospects for the use of probiotics for prevention and treatment of bird disbacteriosis’ [Perspektyvy vykorystannia probiotykiv dlia profilaktyky ta likuvannia dysbakterioziv ptakhiv], Bulletin of Problems Biology and Medicine [Visnyk problem biolohii i medytsyny], 4(2), p. 77–84. doi: 10.29254/2077-4214-2018-4-2-147-77-84.

DSSU [State Committee for Technical Regulation and Consumer Policy] (2005) DSTU 4483:2005. Veterinary Immunobiological Preparations. Methods for Determination of Bacterial and Fungous Contamination [Preparaty veterynarni imunobiolohichni. Metody vyznachannia bakterialnoi i hrybkovoi kontaminatsii]. Kyiv: Derzhspozhyvstandart Ukrainy. [in Ukrainian].

Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., Verbeke, K. and Reid, G. (2017) ‘Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics’, Nature Reviews Gastroenterology & Hepatology, 14(8), pp. 491–502. doi: 10.1038/nrgastro.2017.75.

Gujvinska, S. O. (2015) ‘Determination of storage stability of the probiotics’ [Vyznachennia stabilnosti probiotyka u protsesi zberihannia], Veterinary Medicine [Veterynarna medytsyna], 101, pp. 208–211. Available at: https://jvm.kharkov.ua/sbornik/101/10_61.pdf. [in Ukrainian].

Gujvinska, S. O. and Paliy, A. P. (2018) ‘Determination of antagonistic and adhesive properties of lactobacterium and bifidobacterium’ [Vyznachennia antahonistychnykh ta adhezyvnykh vlastyvostei laktobakterii ta bifidobakterii], Microbiological Journal [Mikrobiolohichnyi Zhurnal], 80(1), pp. 36–44. doi: 10.15407/microbiolj80.01.036. [in Ukrainian].

Hardy, A. (2023) How Prebiotics Help Gut Health. Available at: https://ignitenutrition.ca/blog/how-prebiotics-help-gut-health.

Iegorov, B., Kananykhina, O. and Turpurova, T. (2021) ‘Probiotic feed additives in fattening of agricultural animals’, Grain Products and Mixed Fodder’s, 21(4), pp. 25–31. doi: 10.15673/gpmf.v21i4.2250.

Kolechko, A. V., Chudak, R. A. and Shpakovska, H. I. (2023) Effectiveness of Probiotic Preparations in Animal Husbandry [Efektyvnist zastosuvannia probiotychnykh preparativ v tvarynnytstvi]. Vinnytsia: Druk Ltd. Available at: http://repository.vsau.org/getfile.php/33612.pdf. [in Ukrainian].

MHU (The Ministry of Health of Ukraine) (2004) 42-3.3:2004. Quality Guidelines. Medicinal Products. Stability Testing [42-3.3:2004. Nastanova z yakosti. Likarski zasoby. Vyprobuvannia stabilnosti]. Kyiv: The Ministry of Health of Ukraine. Available at: https://compendium.com.ua/uk/clinical-guidelines-uk/standartizatsiya-farmatsevtichnoyi-produktsiyi-tom-1/st-n-mozu-42-3-3-2004. [in Ukrainian].

Mizernytskyi, O. (2021) ‘Use of probiotics in poultry’ [Vykorystannia probiotykiv u ptakhivnytstvi], Modern Poultry [Suchasne ptakhivnytstvo], 1–2, pp. 12–15. Available at: http://nbuv.gov.ua/UJRN/Sps_2021_1-2_7. [in Ukrainian].

Roberfroid, M. B. (2000) ‘Prebiotics and probiotics: are they functional foods?’, The American Journal of Clinical Nutrition, 71(6), pp. 1682S–1687S. doi: 10.1093/ajcn/71.6.1682S.

Solovyova, A. and Kaliuzhnaia, O. (2021) ‘Study of stability of semi-solid drug “Probioskin” for skin application in the process of storage’ [Doslidzhennia stabilnosti miakoho preparatu dlia nashkirnoho zastosuvannia “Probioskin” u protsesi zberihannia], Annals of Mechnikov’s Institute, 4, pp. 85–90. Available at: https://journals.uran.ua/ami/article/view/245914. [in Ukrainian].

Swanson, K. S., Gibson, G. R., Hutkins, R., Reimer, R. A., Reid, G., Verbeke, K., Scott, K. P., Holscher, H. D., Azad, M. B., Delzenne, N. M. and Sanders, M. E. (2020) ‘The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics’, Nature Reviews Gastroenterology & Hepatology, 17(11), pp. 687–701. doi: 10.1038/s41575-020-0344-2.

Taboada, N., Fernández Salom, M., Córdoba, A., González, S. N., López Alzogaray, S. and Van Nieuwenhove, C. (2022) ‘Administration of selected probiotic mixture improves body weight gain and meat fatty acid composition of creole goats.’, Food Bioscience, 49, p. 101836. doi: 10.1016/j.fbio.2022.101836.

Tavaria, F. K. (2017) ‘Topical use of probiotics: The natural balance’, Porto Biomedical Journal, 2(3), pp. 69–70. doi: 10.1016/j.pbj.2017.02.003.

Van Emden, H. F. (2019) Statistics for Terrified Biologists. 2^nd ed. Hoboken, NJ: John Wiley & Sons. ISBN 9781119563679.

Vovk, S. O., Dmytrotsa, A. I., Polovyj, I. V. and Buchynskyj, V. M. (2021) ‘Probiotics in animal and poultry feeding’ [Probiotyky v hodivli tvaryn i ptytsi], Foothill and Mountain Agriculture and Stockbreeding [Peredhirne ta hirske zemlerobstvo i tvarynnytstvo], 69(1), pp. 157–168. Available at: http://nbuv.gov.ua/UJRN/pgzt_2021_69(1)__12. [in Ukrainian].