Journal for Veterinary Medicine, Biotechnology and Biosafety

Volume 11, Issue 3, September 2025, Pages 9–15

ISSN 2411-3174 (print version) ISSN 2411-0388 (online version)

FEATURES OF CLINICAL MANIFESTATIONS AND PATHOMORPHOLOGICAL CHARACTERISTICS OF BORDETELLOSIS IN DOGS

Hadzevych D. V.

National Scientific Center ‘Institute of Experimental and Clinical Veterinary Medicine’, Kharkiv, Ukraine, e-mail: d5195681@gmail.com

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Citation for print version: Hadzevych, D. V. (2025) ‘Features of clinical manifestations and pathomorphological characteristics of Bordetellosis in dogs’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 11(3), pp. 9–15.

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Citation for online version: Hadzevych, D. V. (2025) ‘Features of clinical manifestations and pathomorphological characteristics of Bordetellosis in dogs’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 11(3), pp. 9–15. DOI: 10.36016/JVMBBS-2025-11-3-2.

Summary. The results of the studies showed that the clinical signs of Bordetella infection in dogs are pronounced and have characteristic manifestations. These signs typically last for three to four months and then disappear. The most pronounced symptom was coughing, ranging from a rare, mild, productive cough to a severe, dry cough accompanied by suffocation attacks and vomiting. We recorded the most pronounced damage and typical pathomorphological changes in the respiratory organs of all dead dogs. The mucous membranes of the trachea and bronchi were hyperemic, and their lumens contained foamy sputum. Signs of catarrhal or catarrhal-purulent inflammation, emphysema, and hyperemia were detected in the lungs. A heterogeneous, spotted, marbled pattern was observed on the surface of the lungs, especially in the dorsal regions, which is characteristic of this infection. According to our studies, the infection was found in animals of all age groups. However, it was more frequently recorded and proceeded particularly severely in puppies aged two to five weeks and six months. In most cases, bordetellosis resulted in recovery following adequate etiological and symptomatic therapy; however, complications and animal deaths were frequently reported. According to our observations, mortality was low in complicated cases, ranging from 7% to over 22%

Keywords: Bordetella bronchiseptica, tracheobronchitis, bronchoalveolar lavage, nasopharyngeal secretion

References:

Avramenko, N. O. (1999) ‘Measures to combat pneumonia of associated etiology’ [Zakhody borotby z pnevmoniiamy asotsiiovanoi etiolohii], Bulletin of Sumy National Agrarian University. Series: Veterinary Medicine [Visnyk Sumskoho natsionalnoho ahrarnoho universytetu. Seriia: Veterynarna medytsyna], 4, рр138–139. [in Ukrainian].

De la Torre, M. J. L., De la Fuente, C. G., De Alegría, C. R., Del Molino, C. P., Agüero, J. and Martínez-Martínez, L. (2012) ‘Recurrent respiratory infection caused by Bordetella bronchiseptica in an immunocompetent infant’, The Pediatric Infectious Disease Journal, 31(9), рр981–983. doi: 10.1097/inf.0b013e31825d2e84.

El Khatib, N., Ferroni, A., Le Bourgeois, M., Chedevergne, F., Clairicia, M., Avril, H., Guiso, N. and Sermet-Gaudelus, I. (2015) ‘Persistent Bordetella bronchiseptica infection in a child with cystic fibrosis: Relationship to bacterial phenotype’, Journal of Cystic Fibrosis, 14(5), ррE13E15. doi: 10.1016/j.jcf.2015.03.014.

Gadzevich, D. V. (2024) ‘Study of the effectiveness of using a selective cephalexin component in a CCA nutrient medium for the detection of clinical isolates of Bordetella bronchiseptica’ [Vyvchennia efektyvnosti zastosuvannia selektyvnoho komponentu tsefaleksyn u pozhyvnomu seredovyshchi KVA dlia vydilennia klinichnykh izoliativ Bordetella bronchiseptica], Veterinary Medicine [Veterynarna medycyna], 110, рр. 81–87. doi: 10.36016/vm-2024-110-12. [in Ukrainian].

Gerlach, G., von Wintzingerode, F., Middendorf, B. and Gross, R. (2001) ‘Evolutionary trends in the genus Bordetella, Microbes and Infection, 3(1), pp. 61–72. doi: 10.1016/s1286-4579(00)01353-8.

Gueirard, P., Weber, C., Le Coustumier, A. and Guiso, N. (1995) ‘Human Bordetella bronchiseptica infection related to contact with infected animals: Persistence of bacteria in host’, Journal of Clinical Microbiology, 33(8), рр2002–2006. doi: 10.1128/jcm.33.8.2002-2006.1995.

Hadzevych, D. V. (2024) ‘Bacteriological studies of probe swabs with nasopharyngeal secretions from canines diagnosed with Bordetellosis’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 10(4), рр33–39. doi: 10.36016/jvmbbs-2024-10-4-6.

Huebner, E. S., Christman, B., Dummer, S., Tang, Y. W. and Goodman, S. (2006) ‘Hospital-acquired Bordetella bronchiseptica infection following hematopoietic stem cell transplantation’, Journal of Clinical Microbiology, 44(7), рр. 2581–2583. doi: 10.1128/jcm.00510-06.

Khanna, M., Fan, J., Pehler-Harrington, K., Waters, C., Douglass, P., Stallock, J., Kehl, S. and Henrickson, K. J. (2005) ‘The pneumoplex assays, a multiplex PCR-enzyme hybridization assay that allows simultaneous detection of five organisms, Mycoplasma pneumoniae, Chlamydia (Chlamydophila) pneumoniae, Legionella pneumophila, Legionella micdadei, and Bordetella pertussis, and its real-time counterpart’, Journal of Clinical Microbiology, 43(2), рр565–571. doi: 10.1128/jcm.43.2.565-571.2005.

Korniienko, L. Ye., Busol, V. O., Nedosiekov, V. V., Ushkalov, V. O., Holovko, A. M., Korniienko, L. V. and Dombrovskyi, O. B. (2008) Chronic Infectious Diseases of Animals [Khronichni infektsiini khvoroby tvaryn]. Bila Tserkva: Bila Tserkva National Agrarian University. Available at: https://rep.btsau.edu.ua/handle/BNAU/1294.

MHU (Ministry of Health of Ukraine) (2005) Methodological Guidelines for Microbiological Diagnostics of Pertussis and Parapertussis: approved by the order of the Ministry of Health of Ukraine of 15 April 2005 No. 169’ [Metodychni vkazivky z mikrobiolohichnoi diahnostyky kashliuku ta parakashliuku: zatverdzheno nakazom Ministerstva okhorony zdorovia Ukrainy vid 15 kvitnia 2005 r. № 169]. Available at: https://mozdocs.kiev.ua/view.php?id=3910. [in Ukrainian].

MHU (Ministry of Health of Ukraine) (2007) Methodological Guidelines ‘Determination of the Sensitivity of Microorganisms to Antibacterial Drugs’: approved by the order of the Ministry of Health of Ukraine of 5 April 2007 No. 167’ [Metodychni vkazivkyVyznachennia chutlyvosti mikroorhanizmiv do antybakterialnykh preparativ”: zatverdzheno nakazom Ministerstva okhorony zdorovia Ukrainy vid 5 kvitnia 2007 r. № 169]. Available at: https://mozdocs.kiev.ua/view.php?id=6958. [in Ukrainian].

Milanko, A. Ya., Gerilovich, P. P. and Dushkin, D. V. (1995) ‘Bordetella bronchiseptica infection in dogs’ [Bordetelleznaya infektsiya sobak], Proceeding of Scientific Conference of the Kharkov Zooveterinary Institute [Materialy nauchnoj konferencii Harkovskogo zooveterinarnogo instituta], pp. 34–35. [in Russian].

Milanko, A. Ya., Kholodylo, Ye. V. and Dushkyn, D. V. (1995) ‘The role of Bordetella bronchiseptica in the diagnosis of whooping cough-like diseases’ [RolBordetella bronchiseptica v diagnostike koklyushepodobnykh zabolevaniy], Proceedings of the IV Congress of Parasitocenologists of Ukraine [Materialy IV s”ezda parazitotsenologov Ukrainy], p. 14. [in Russian].

Mylanko, O. Ya. and Dushkin, D. V. (1996) ‘Properties of Bordetella bronchiseptica cultures isolated from dogs’ [Vlastyvosti kultur Bordetella bronchiseptica vydilenykh vid sobak], Proceeding of Scientific Conference of the Sumy Agricultural Institute [Materialy naukovoi konferentsii Sumskoho Silskohospodarskoho Instytutu], pp. 47–49. [in Ukrainian].

Spilker, T., Liwienski, A. A. and LiPuma, J. J. (2008) ‘Identification of Bordetella spp. in respiratory specimens from individuals with cystic fibrosis’, Clinical Microbiology and Infection, 14(5), рр504–506. doi: 10.1111/j.1469-0691.2008.01968.x.

Versalovic, J., Carroll, K. C., Funke, G., Jorgensen, J. H., Landry, M. L. and Warnock, D. W. (eds.). (2011) Manual of Clinical Microbiology. 10th ed. Washington, DC: ASM Press. doi: 10.1128/9781555816728.