Journal for Veterinary Medicine, Biotechnology and Biosafety
Volume
11, Issue 4, November 2025, Pages 18–23
ISSN 2411-3174 (print version) ISSN 2411-0388
(online version)
COMPARATIVE
ANTIPARASITIC EFFECTIVENESS OF THE COMBINED DRUG AND NIFULIN IN THE TREATMENT OF BLASTOCYSTOSIS
AND HISTOMONIASIS IN TURKEYS
Bogach M. V., Rachynskyi A. S.,
Dunaiev Yu. K., Bohach O. M.
1 National
Scientific Center ‘Institute of Experimental and Clinical Veterinary
Medicine’, Kharkiv, Ukraine, e-mail: bogach_nv@ukr.net
2 Institute of
Animal Biology of the National Academy of Agrarian Sciences of Ukraine, Lviv, Ukraine
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PDF (print version)
Citation for print version: Bogach, M. V.,
Rachynskyi, A. S., Dunaiev, Yu. K. and Bohach, O. M. (2025) ‘Comparative antiparasitic effectiveness of the combined drug and Nifulin in the treatment of Blastocystosis
and Histomoniasis in turkeys’, Journal for Veterinary
Medicine, Biotechnology and Biosafety, 11(4), pp. 18–23.
Download
PDF (online version)
Citation for online version: Bogach, M. V.,
Rachynskyi, A. S., Dunaiev, Yu. K. and Bohach, O. M. (2025) ‘Comparative antiparasitic effectiveness of the combined drug and Nifulin in the treatment of Blastocystosis
and Histomoniasis in turkeys’, Journal for Veterinary
Medicine, Biotechnology and Biosafety, 11(4), pp. 18–23. DOI: 10.36016/JVMBBS-2025-11-4-3.
Summary. For decades, effective drugs have been used
to prevent and treat protozoosis in Europe, the
United States, and other countries. However, these drugs were subsequently
withdrawn from use for consumer safety reasons. Since then, research has
focused on finding alternative approaches, ranging from new chemotherapeutic
agents to plant-based compounds. Using phytogenic substances in turkey feed is
considered promising because they are effective and act as antioxidants. This
study aimed to compare the effectiveness of domestic antiprotozoal drugs and a
newly developed drug containing plant components against protozoosis
in turkeys. The developed combined drug, which includes the antiprotozoal
substances metronidazole and furazolidone, as well as
the plant components garlic powder (Allium sativum)
and tansy (Tanacetum vulgare),
demonstrated a rapid and sustained reduction in mean infection intensity in turkeys,
particularly on days 7–14 of treatment. The combined drug’s
effectiveness exceeded that of Nifulin, evidenced by
a significant reduction in pathogen numbers and complete Blastocystis spp.
elimination by day 14. By day 7, the intensity of the infection
decreased by more than 78%. By day 14, the infection was completely
eradicated (prevalence — 0%, effectiveness — 100%). When Nifulin was used, however, 21.4% of turkeys remained
infected. The drug also provided higher effectiveness at all stages of histomoniasis treatment. On day 14, only 7.1% of
turkeys were infected, compared to 14.3% in the Nifulin
group. The respective effectiveness was 92.9% and 78.6%.
Keywords: antiprotozoal
drugs, metronidazole, furazolidone, Allium sativum, Tanacetum vulgare
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