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Journal for Veterinary Medicine, Biotechnology and Biosafety

Volume 11, Issue 4, November 2025, Pages 3–11

ISSN 2411-3174 (print version) ISSN 2411-0388 (online version)

EFFECT OF ZINC CARBONATE NANOPARTICLES SUBCHRONIC INTAKE ON ANTIOXIDANT STATUS OF MALE RABBITS

Koshevoy V. I. ¹, Naumenko S. V. ¹, Bespalova I. I. ², Yefimova S. L. ²

¹ State Biotechnological University, Kharkiv, Ukraine, e-mail: koshevoyvsevolod@gmail.com

² Institute for Scintillation Materials of the National Academy of Sciences of Ukraine, Kharkiv, Ukraine

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Citation for print version: Koshevoy, V. I., Naumenko, S. V., Bespalova, I. I. and Yefimova, S. L. (2025) ‘Effect of zinc carbonate nanoparticles subchronic intake on antioxidant status of male rabbits’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 11(4), pp. 3–11.

Download PDF (online version)

Citation for online version: Koshevoy, V. I., Naumenko, S. V., Bespalova, I. I. and Yefimova, S. L. (2025) ‘Effect of zinc carbonate nanoparticles subchronic intake on antioxidant status of male rabbits’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 11(4), pp. 3–11. DOI: 10.36016/JVMBBS-2025-11-4-1.

Summary. An urgent scientific task is to develop modern and safe zinc-based nanoparticles that can fulfill rabbits’ need for this essential mineral. This research primarily focuses on enhancing the bioavailability of zinc and reducing its toxic properties. To evaluate the antioxidant effect of zinc carbonate nanoparticles, 24 sexually mature male Hiplus rabbits were used, which were randomly divided into two groups of four animals and three replicates each. The rabbits in the experimental group were orally administered zinc carbonate nanoparticles obtained by the co-precipitation method and stabilized with polyvinylpyrrolidone at a dose of 100 mg/kg body weight for 30 days. Animals in the control group received distilled water according to a similar procedure. At the end of the experiment, blood samples were taken from all animals for biochemical studies. The presence of redox activity of these nanoparticles in the organism of male rabbits was established: after administration in the experimental group of animals, a significant decrease in peroxidation markers was noted: the level of thiobarbiturate-active products by 24.5%, diene conjugates by 18.7% and lipid hydroperoxides by 16.2% (p < 0.05). A significant increase in the total antioxidant activity (by 40.2%), the content of enzymatic and non-enzymatic components of the antioxidant defense system was confirmed by the expressive antioxidant effect of zinc carbonate nanoparticles: superoxide dismutase activity by 68.9%, catalase by 18.3%, glutathione peroxidase by 27.6%, glutathione reductase by 34.6% and reduced glutathione content by 15.7% (p < 0.05). Thus, it can be argued that there is an antioxidant effect of zinc carbonate nanoparticles for male rabbits. The authors of the article consider the study of the effect of these nanoparticles on the state of sexual function in rabbits, as well as pharmacokinetic studies, to be prospects for further research

Keywords: bioavailability, toxicity, blood, biochemical parameters

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