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Journal for Veterinary Medicine, Biotechnology and Biosafety

Volume 12, Issue 3, September 2026, Pages 3–11

ISSN 2411-3174 (print version) ISSN 2411-0388 (online version)

EFFECT OF POLYPHENOL COMPLEX FROM VITIS VINIFERA L. ON FEMALE DOGS IN THE POSTPARTUM PERIOD

Parakhnych I. R., Koshevoy V. I.

State Biotechnological University, Kharkiv, Ukraine, e-mail: koshevoyvsevolod@gmail.com

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Citation for print version: Parakhnych, I. R. and Koshevoy, V. I. (2026) ‘Effect of polyphenol complex from Vitis vinifera L. on female dogs in the postpartum period’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 12(3), pp. 3–11.

Download PDF (online version)

Citation for online version: Parakhnych, I. R. and Koshevoy, V. I. (2026) ‘Effect of polyphenol complex from Vitis vinifera L. on female dogs in the postpartum period’, Journal for Veterinary Medicine, Biotechnology and Biosafety, 12(3), pp. 3–11. DOI: 10.36016/JVMBBS-2026-12-3-1.

Summary. This paper presents the results of a study investigating the effects of the polyphenolic complex Vitis vinifera L. (PCV) on the antioxidant status, liver function, hormonal profile, and innate immunity of female dogs in the postpartum period. The use of PCV was found to be accompanied by a significant decrease in the intensity of lipoperoxidation processes (Thiobarbituric acid reactive substances (TBARS) content and lipid hydroperoxide levels) and an increase in the activity of the endogenous antioxidant system (blood plasma total antioxidant activity, catalase activity, superoxide dismutase activity, and reduced glutathione levels), indicating its membrane-stabilizing and antioxidant effects. Along with the normalization of free radical metabolism, there was a decrease in hepatospecific enzyme activity, reflecting reduced cytolytic damage to hepatocytes and improved liver function. The hormonal profile of the female dogs remained stable with respect to thyroid hormones and estradiol. However, there was a trend toward lower cortisol, insulin, and progesterone levels, which may be associated with reduced metabolic and inflammatory stress. Immunological studies revealed an upward trend in serum bactericidal and lysozyme activity, as well as increased neutrophil phagocytic activity and phagocytic index. This reflects the optimization of innate immunity under the influence of the complex. The obtained data indicate PCV’s multifaceted physiological effects aimed at restoring antioxidant balance, protecting the liver, reducing stress-induced endocrine shifts, and strengthening the immune system in female dogs during the postpartum period

Keywords: therapy, oxidative stress, antioxidant system, immune system, metabolism

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